Selection of MicroRNAs Associated between Neural Stem Cells and Multiple Sclerosis

Background: Diagnosis and treatment of multiple sclerosis (MS) in its advanced state have been one the medical community's concerns so far. Cell therapy has a modern successful treatment. However, it not yet effective enough to treat MS. This study aimed find relationship between neural stem cells (NSCs) MS, by considering important signaling pathways pathogenesis, most microRNAs (miRNAs) for diagnosis were investigated. Materials Methods: Using bioinformatics approaches appropriate databases, NSCs MS recognized, after obtaining common genes them, protein products them evaluated. Finally, nominating essential genes, we isolated analyzed microarrays involved these pathways. Results: In first step, 76 upregulated 1600 down-regulated recognized. Upregulated obtained axon guidance, NCAM, RHO pathways, cell cycle, RNA metabolism, DNA repair genes. Then, high-expression PAK3, ROBO2, LIMK2, low-expression AURKA, BIRC5, BLM, BRCA1 proteins identified. Accordingly, miRNAs included hsa-miR-4790-5p, hsa-miR-4281, hsa-miR-4327, but hsa-miR-103b, hsa-miR-638, hsa-miR-4537 Conclusion: Our indicated that abovementioned major role diagnosing treating